智宽东

生物

志宽在台湾长大, received his BS from National Taiwan University and PhD from Princeton University, 都是物理上的. He then took up postdoc positions at Hong Kong University of Science and Technology, 匹兹堡大学, 和康奈尔大学, 在加入A之前&2006年在T学院任教. 从普林斯顿大学, his re搜索 has focused on using micro/nanofabricated devices for biological applications. 康奈尔大学, Chih-kuan noticed that sperm exhibit interesting emergent behaviors, which became his current re搜索 focus. Trained as a physicist, he is interested in the fundamental physics in living systems.

研究兴趣

生物物理, microfluidic in vitro models for biological systems, collective dynamics and phase separation of cells. 软质和活性物质. Influence of physical environment on mammalian sperm motility.

最近的出版物

• Shiva Phuyal, 苏珊·苏亚雷斯, 智宽东. 医学杂志ogical benefits of collective swimming of sperm in a viscoelastic fluid. 前面. 电池开发. 医学杂志.10, pp. 921623. (2022).
• 齐广东，苏亚雷斯. Co-adaptation of Physical Attributes of the Mammalian Female Reproductive Tract and Sperm to Facilitate Fertilization. 细胞10,pp. 1297, (2021).
• Benjamin Walker, Shiva Phuyal, Kenta lshimoto, 智宽东, Eamonn Gaffney. Computer-assisted beat-pattern analysis and the fagellar waveforms of bovine spermatozoa. Royal Society Open Science 7, pp. 200769 (2020).
• Chungwei林, Tim Marks, Milutin Pajovic, Shinji Watanabe, 智宽东. Model parameter learning using Kullback-Leibler divergence. 《美国线上赌场》491页. 549 (2018).
• 智宽东, Chungwei林, 本尼迪克特哈维, 阿莉莎菲奥雷, 的卡墩, 明明吴, 苏珊·苏亚雷斯. Fluid viscoelasticity promotes collective swimming of sperm. 科学报告7，页. 3152 (2017).
• 魏的歌, 智宽东, Yen-Chun陆, Yehudah帕尔多, 明明吴, Moumita Das, Der-I花王, Shuibing陈, Minglin马. Dynamic self-organization of microwell-aggregated cellular mixtures. 软物质12页. 5739 (2016).
• 的卡墩, 罗斯Markello, 连胡, 多伊奇谢拉, 智宽东, Walaa Alshafie, 托马斯·雅鲁, 罗伯特•吉尔伯特, 明明吴, 苏珊·苏亚雷斯. Dynamics of bull sperm interaction with epithelium differ between oviductal isthmus and ampulla. 医学杂志ogy of Reproduction 95(4), pp. 90 (2016).
• Beum Kim, Lubna Richter, Nicholas Hatter, 智宽东, Beth Ahner, 明明吴. An array microhabitat system for high throughput studies of microalgal growth under controlled nutrient gradients. 芯片上的实验15(18)，pp. 3687 (2015).
• 智宽东, 的卡墩, Anubhab Roy, Donald Koch, 苏珊·苏亚雷斯, 明明吴. Emergence of upstream swimming via a hydrodynamic transition. Physical Review Letters 114(10), pp. 108102 (2015).
• Yu Huang, 智宽东, Anqi Zheng, Beum Kim, 明明吴. Interstitial flows promote amoeboid over mesenchymal motility of breast cancer cells revealed by a three dimensional microfluidic model. 综合生物学7(11)，pp. 1402 (2015).
• 智宽东, 连胡, 阿莉莎菲奥雷, 的卡墩, 狄龙Hickman, 罗伯特•吉尔伯特, 苏珊·苏亚雷斯, 明明吴. Microgrooves and fluid flows provide preferential passageways for sperm over pathogen Tritrichomonas胎儿. Proceedings of the National Academy of Sciences 112(17), pp. 5431 (2015).
• 智宽东, 的卡墩, 阿莉莎菲奥雷, 苏珊·苏亚雷斯, 明明吴. Cooperative roles of biological flow and surface topography in guiding sperm migration revealed by a microfluidic model. 芯片上的实验14(7)，pp. 1348, (2014).
• 智宽东, Oleh Krupa, Elif Apaydin, Jr-Jiun Liou, Anthony Diaz-Santana, Beum Kim, 明明吴. A contact line pinning based microfluidic platform for modelling physiological flows. 芯片上的实验13(19)，页. 3876 (2013).
• Bret Davis, Junhan Pan, 智宽东, 罗伯特·奥斯汀, 罗伯特Riehn. Sensing DNA with alternating currents using a nanogap sensor embedded in a nanochannel device. 纳米生命3(01)，pp. 1340007, (2013).
• 汉娜萨勒曼, 由布伦纳, 智宽东, 诺亚Elyahu, 兰德Stolovicki, 林赛·摩尔, 艾伯特Libchaber, Erez布劳恩. Universal protein fluctuations in populations of microorganisms. Physical Review Letters 108(23), pp. 238105 (2012).
• Qiucen张, Guillaume兰伯特, 大卫·廖, Hyunsung金, Kristelle罗宾, 智宽东, 纳德布尔曼德, 罗伯特·奥斯汀. Acceleration of emergence of bacterial antibiotic resistance in connected microenvironments. 科学333(6050)，页. 1764–1767 (2011).
• 罗伯特·奥斯汀, 智宽东, Guillaume兰伯特, 大卫·廖, Xiuqing Gong. An introduction to micro-ecology patches. Chemical Society Reviews 39(3), pp. 1049–1059 (2010).
• 智宽东, 罗伯特Riehn, 罗伯特·奥斯汀. Complementary metal oxide semiconductor compatible fabrication and characterization of parylene-C covered nanofluidic channels with integrated nanoelectrodes. 生物微流体学报3(3)，pp. 031101 (2009).
• Shuang Lim, 罗伯特Riehn, 智宽东, William Ryu, Rui Zhuo, Joanna Dalland, 罗伯特·奥斯汀. (Upconverting nanophosphors for bioimaging). (40) 20, pp. 405701. 纳米技术(2009).
• 罗伯特Riehn, 沃尔特Reisner, 乔纳斯Tegenfeldt, 王阎, 智宽东, Shuang-Fang Lim, 爱德华·考克斯, 詹姆斯Sturm, 基思•莫顿, 史蒂文周, 其他(2007). (Nanochannels for Genomic DNA Analysis: The Long and the Short of It). pp. 151–186. Integrated 生物chips for DNA Analysis.
• Chih-Yuan萧, 日元的太阳, 梁伟陈, 智宽东, 温罗, Jiunn-Wen苏, Sung-Jan林, Shiou-Hwa Jee, Gwo-Jen简, 董身份. Effects of different immersion media in multiphoton imaging of the epithelium and dermis of human skin. Microscopy 研究 and Technique 69(12), pp. 992–997 (2006).
• Shuang Lim, 罗伯特Riehn, William Ryu, Nora Khanarian, 智宽东, David Tank, 罗伯特·奥斯汀. In vivo and scanning electron microscopy imaging of upconverting nanophosphors in Caenorhabditis elegans. 纳米快报6(2)，pp. 169–174 (2006).
• 智宽东, 日元的太阳, 温罗, Sung-Jan林, Shiou-Hwa Jee, 董身份. Effects of objective numerical apertures on achievable imaging depths in multiphoton microscopy. Microscopy 研究 and Technique 65(6), pp. 308–314 (2004).
• 齐广东，苏亚雷斯. Co-adaptation of Physical Attributes of the Mammalian Female Reproductive Tract and Sperm to Facilitate Fertilization. 细胞10,pp. 1297 (2021).